Structure of PDB 5jhq Chain B Binding Site BS02

Receptor Information

>5jhq Chain B (length=461) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

ALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDV
VEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNW
NYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLT
GEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNR
VRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAM
DLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELR
ERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVA
SLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHG
AKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMG
NEAVQQILSES

Ligand information

>5jhq Chain H (length=10) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

YRQSPDGACS

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5jhq Tankyrase-1 Ankyrin Repeats Form an Adaptable Binding Platform for Targets of ADP-Ribose Modification.
Resolution	3.2 Å
Binding residue (original residue number in PDB)	R368 S370 L375 G378 Y379 L403 N408 S411 Y412 H414 D432 F436 E441
Binding residue (residue number reindexed from 1)	R187 S189 L194 G197 Y198 L222 N227 S230 Y231 H233 D251 F255 E260

Enzymatic activity

Enzyme Commision number

2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.

External links

PDB	RCSB:5jhq, PDBe:5jhq, PDBj:5jhq
PDBsum	5jhq
PubMed	27594684
UniProt	O95271\|TNKS1_HUMAN Poly [ADP-ribose] polymerase tankyrase-1 (Gene Name=TNKS)

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