Structure of PDB 5jej Chain B Binding Site BS02

Receptor Information
>5jej Chain B (length=233) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ENPLKRLLVPGEEWEFEVTAFYRGRQVFQQTISCPEGLRLVGSEVGDRTL
PGWPVTLPDPGMSLTDRGVMSYVRHVLSCLGGGLALWRAGQWLWAQRLGH
CHTYWAVSEELLPNSGHGPDGEVPKDKEGGVFDLGPFIVDLITFTEGSGR
SPRYALWFCVGESWPQDQPWTKRLVMVKVVPTCLRALVEMARVGGASSLE
NTVDLHISNSHPLSLTSDQYKAYLQDLVEGMDF
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5jej Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		R211 V257 Y260
Binding residue
(residue number reindexed from 1)		R23 V69 Y72
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5jej, PDBe:5jej, PDBj:5jej
PDBsum5jej
PubMed27302953
UniProtQ14653|IRF3_HUMAN Interferon regulatory factor 3 (Gene Name=IRF3)

[Back to BioLiP]