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Receptor Information

>5jc7 Chain B (length=647) Species: 9031 (Gallus gallus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

DLTLRDYQMEVAKPALNGENIIICLPTGSGKTRVAVYITKDHLDKKRKAS
EQGKVIVLVNKVPLVEQHLRKEFNPFLKHWYQVIGLSGDSELKISFPEVV
KRYDVIICTAQILENSLLNESVRLSDFSLIIIDQCHHTQKEGVYNNIMRR
YLKEKIKNRPQPQILGLTASPGVGGARSNSKAEEHILKICANLDACRIMT
VKEHASQLKNQVKEPFKKTVIADDKRRDPFRERIIEIMQDIQKYCQLYPK
SEFGSQPYEQWVIREERRAAKEEKRKERVCAEHLKKYNDALQINDTIRMV
DAYNHLNNFYKELKRRKTAESPLVSKQDETDEFLMRLFHAKKKQLKELAR
KPEYDNEKLMKLRNTLMEEFTKTEEPRGIIFTKTRQSALALYHWIMDNPK
FEEVGIKAHFLIGAGHNSETKPMTQNEQREVIDKFRGGSINLLIATTVAE
EGLDIKECNIVIRYGLVTNEIAMVQARGRARADESTYALVASSGSGAVER
EDVNIFRENMMYKAIRRVQEMPPEEYLNKIQDFQLQSIVEKQMKAKRDQR
ITFLCKNCHKLICSGEDIQVIENMHHVSVKKDFQHLYHKREEIICKDCGQ
VWGNMMVYRGLDLPCLKIRNFVVAFETTKEIFKKWGELPIIFPDFDY

>5jc7 Chain Y (length=24) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

gggacgucaugcgcaugacguccc

........................

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5jc7 Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5.
Resolution	2.75 Å
Binding residue (original residue number in PDB)	K442 E443 Q568 P569 Q572 H733 T785 R817 K861 M900 H901
Binding residue (residue number reindexed from 1)	K140 E141 Q256 P257 Q260 H416 T468 R500 K544 M574 H575

Enzyme Commision number

3.6.4.13: RNA helicase.

	Molecular Function
GO:0003677	DNA binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity

PDB	RCSB:5jc7, PDBe:5jc7, PDBj:5jc7
PDBsum	5jc7
PubMed	27203181
UniProt	D9N195

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Structure of PDB 5jc7 Chain B Binding Site BS02