Structure of PDB 5iz8 Chain B Binding Site BS02

Receptor Information
>5iz8 Chain B (length=322) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HHHHHHMLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPA
VCVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRR
YAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLR
NLSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHC
TENKADICAVDGALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATN
EDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALW
DMSMLKNLIHSKHKMIAMGSAA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5iz8 Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.
Resolution3.06 Å
Binding residue
(original residue number in PDB)		F458 T506 N507 F510 G511 K516 R549 N550 W553 S590 W593 N594
Binding residue
(residue number reindexed from 1)		F59 T107 N108 F111 G112 K117 R150 N151 W154 S191 W194 N195
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008013 beta-catenin binding
Biological Process
GO:0030178 negative regulation of Wnt signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:5iz8, PDBe:5iz8, PDBj:5iz8
PDBsum5iz8
PubMed28759015
UniProtP25054|APC_HUMAN Adenomatous polyposis coli protein (Gene Name=APC)

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