Structure of PDB 5iwm Chain B Binding Site BS02

Receptor Information
>5iwm Chain B (length=189) Species: 158879 (Staphylococcus aureus subsp. aureus N315) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KLADCSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILPLRGKILNVEK
ARLDRILNNNEIRQMITAFGTGIGGDFDLAKARYHKIVIMTDADVDGAHI
RTLLLTFFYRFMRPLIEAGYVYIAQPPTGYKGLGEMNADQLWETTMNPEH
RALLQVKLEDAIEADQTFEMLMGDVVENRRQFIEDNAVY
Ligand information
Receptor-Ligand Complex Structure
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PDB5iwm Novel tricyclics (e.g., GSK945237) as potent inhibitors of bacterial type IIA topoisomerases.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		K460 L462 N463 K466 R471 H515 V626 R629
Binding residue
(residue number reindexed from 1)		K44 L46 N47 K50 R55 H99 V176 R179
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:5iwm, PDBe:5iwm, PDBj:5iwm
PDBsum5iwm
PubMed27055939
UniProtP66937|GYRB_STAAN DNA gyrase subunit B (Gene Name=gyrB)

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