Structure of PDB 5iu9 Chain B Binding Site BS02

Receptor Information

>5iu9 Chain B (length=422) Species: 7955 (Danio rerio)

FNLKYTVEEELRAGTKIANVTADAKVAGFALGNRQPYLRVISNSEPRWVN
LSPAGLLITKQKIDRDAVCRQTPKCFISLEVMSNSMEICVIKIEIIDVND
NAPRFPTNHIDIEISENAAPGTRFPLEGASDPDSGSNGIQTYTITPNDIF
GLEIKTRGDGSKIAELVVEKTLDRETQSRYTFELTAEDGGDPPKSGTVQL
NIKVIDSNDNNPVFDEPVYTVNVLENSPINTLVIDLNATDPDEGTNGEVV
YSFINFVSNLTKQMFKIDPKTGVITVNGVLDHEELHIHEIDVQAKDLGPN
SIPAHCKVIVNVIDINDNAPEIKLLSENSEMVEVSENAPLGYVIALVRVS
DNDSGANGKVQCRLQGNVPFRLNEFESFSTLLVDGRLDREQRDMYNLTIL
AEDSGYPPLRSSKSFAVKVTDL

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 5iu9 Chain B Residue 1002

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5iu9 Structural determinants of adhesion by Protocadherin-19 and implications for its role in epilepsy.
• Resolution: 3.59 Å
• Binding residue (original residue number in PDB): E10 D67 D98 V99 D101 D134
• Binding residue (residue number reindexed from 1): E9 D66 D97 V98 D100 D133
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0005509 calcium ion binding

Biological Process

• GO:0007155 cell adhesion
• GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:5iu9, PDBe:5iu9, PDBj:5iu9
• PDBsum: 5iu9
• PubMed: 27787195
• UniProt: F8W3X3|PCD19_DANRE Protocadherin-19 (Gene Name=pcdh19)