Structure of PDB 5ijz Chain B Binding Site BS02

Receptor Information
>5ijz Chain B (length=447) Species: 196627 (Corynebacterium glutamicum ATCC 13032) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MTVDEQVSNYYDMLLKRNAGEPEFHQAVAEVLESLKIVLEKDPHYADYGL
IQRLCEPERQLIFRVPWVDDQGQVHVNRGFRVQFNSALGPYKGGLRFHPS
VNLGIVKFLGFEQIFKNSLTGLPIGGGKGGSDFDPKGKSDLEIMRFCQSF
MTELHRHIGEYRDVPAGDIGVGGREIGYLFGHYRRMANQHESGVLTGKGL
TWGGSLVRTEATGYGCVYFVSEMIKAKGESISGQKIIVSGSGNVATYAIE
KAQELGATVIGFSDSSGWVHTPNGVDVAKLREIKEVRRARVSVYADEVEG
ATYHTDGSIWDLKCDIALPCATQNELNGENAKTLADNGCRFVAEGANMPS
TPEAVEVFRERDIRFGPGKAANAGGVATSALEMQQNASRDSWSFEYTDER
LQVIMKNIFKTCAETAAEYGHENDYVVGANIAGFKKVADAMLAQGVI
Ligand information
Ligand IDAKG
InChIInChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)
InChIKeyKPGXRSRHYNQIFN-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C(O)C(=O)CCC(=O)O
OpenEye OEToolkits 1.7.6C(CC(=O)O)C(=O)C(=O)O
CACTVS 3.385OC(=O)CCC(=O)C(O)=O
FormulaC5 H6 O5
Name2-OXOGLUTARIC ACID
ChEMBLCHEMBL1686
DrugBankDB08845
ZINCZINC000001532519
PDB chain5ijz Chain B Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5ijz Structural insights into domain movement and cofactor specificity of glutamate dehydrogenase from Corynebacterium glutamicum
Resolution2.29 Å
Binding residue
(original residue number in PDB)		K92 G93 G94 Q113 K116 K128 A166 R208 V376 S379
Binding residue
(residue number reindexed from 1)		K92 G93 G94 Q113 K116 K128 A166 R208 V376 S379
Annotation score5
Enzymatic activity
Catalytic site (original residue number in PDB) K128 D168
Catalytic site (residue number reindexed from 1) K128 D168
Enzyme Commision number 1.4.1.4: glutamate dehydrogenase (NADP(+)).
Gene Ontology
Molecular Function
GO:0004353 glutamate dehydrogenase [NAD(P)+] activity
GO:0004354 glutamate dehydrogenase (NADP+) activity
GO:0016491 oxidoreductase activity
GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
Biological Process
GO:0006520 amino acid metabolic process
GO:0006537 glutamate biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5ijz, PDBe:5ijz, PDBj:5ijz
PDBsum5ijz
PubMed25727019
UniProtP31026|DHE4_CORGL NADP-specific glutamate dehydrogenase (Gene Name=gdh)

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