Structure of PDB 5ihe Chain B Binding Site BS02

Receptor Information

>5ihe Chain B (length=442) Species: 272844 (Pyrococcus abyssi GE5)

VVLDKYGYPILYYSKYEDVVIEWNPSVTPVQIEKNYEVKFDVRQVKLRPP
KVEAYASLFKSRLSKLKRILRENPEISNVVDIGKLNYVSGDEEVTIIGLV
NSKRETNRGLIFEVEDKTGIVKVFLPKDSEDYREAFKVLPDAVVAFKGFY
SKKGIFFANKFYLPDVPLYRKQKPPLEEKVYAILISDIHVGSREFCEKAF
LKFLEWLNGHVESKEEEEIVSRVKYLIIAGDVVDGIGIYPGQYSDLVIPD
IFDQYEALANLLANVPEHITMFIGPGNHDAARPAIPQPEFYKEYAKPIYK
LKNAIIISNPAVIRLHGRDFLIAHGRGIEDVVSFVPGKPGLPMVELLKMR
HLAPTFGGKVPIAPDPEDLLVIEEVPDLVQMGHVHVYDAVVYRGVQLVNS
ATWQAQTEFQKMVNIVPTPAKVPVVDVESARVVKVLDFSGWC

Ligand information

• Ligand ID: FE
• InChI: InChI=1S/Fe/q+3
• InChIKey: VTLYFUHAOXGGBS-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: [Fe+3]
• Formula: Fe
• Name: FE (III) ION
• DrugBank: DB13949
• PDB chain: 5ihe Chain B Residue 702

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5ihe Shared active site architecture between archaeal PolD and multi-subunit RNA polymerases revealed by X-ray crystallography.
• Resolution: 2.5 Å
• Binding residue (original residue number in PDB): D360 H362 D404 H562
• Binding residue (residue number reindexed from 1): D187 H189 D231 H385
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.7.7.7: DNA-directed DNA polymerase.
  3.1.11.1: exodeoxyribonuclease I.

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003887 DNA-directed DNA polymerase activity
• GO:0008408 3'-5' exonuclease activity
• GO:0016787 hydrolase activity

Biological Process

• GO:0006260 DNA replication

External links

• PDB: RCSB:5ihe, PDBe:5ihe, PDBj:5ihe
• PDBsum: 5ihe
• PubMed: 27548043
• UniProt: Q9V2F3|DP2S_PYRAB DNA polymerase II small subunit (Gene Name=polB)