Structure of PDB 5ih3 Chain B Binding Site BS02

Receptor Information
>5ih3 Chain B (length=343) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDF
KDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTD
RIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSG
NMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDE
YFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGL
VHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDT
LSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRY
Ligand information
Ligand IDDXE
InChIInChI=1S/C4H10O2/c1-5-3-4-6-2/h3-4H2,1-2H3
InChIKeyXTHFKEDIFFGKHM-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O(C)CCOC
CACTVS 3.341
OpenEye OEToolkits 1.5.0		COCCOC
FormulaC4 H10 O2
Name1,2-DIMETHOXYETHANE
ChEMBLCHEMBL1232411
DrugBankDB01749
ZINCZINC000001690289
PDB chain5ih3 Chain B Residue 507 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5ih3 Crystal structure of mouse CARM1 in complex with SAH at 1.8 Angstroms resolution
Resolution1.77 Å
Binding residue
(original residue number in PDB)		N162 L413 H415
Binding residue
(residue number reindexed from 1)		N28 L279 H281
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) D166 E258 E267 H415
Catalytic site (residue number reindexed from 1) D32 E124 E133 H281
Enzyme Commision number 2.1.1.319: type I protein arginine methyltransferase.
Gene Ontology
Molecular Function
GO:0016274 protein-arginine N-methyltransferase activity
Biological Process
GO:0018216 peptidyl-arginine methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5ih3, PDBe:5ih3, PDBj:5ih3
PDBsum5ih3
PubMed
UniProtQ9WVG6|CARM1_MOUSE Histone-arginine methyltransferase CARM1 (Gene Name=Carm1)

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