Structure of PDB 5i50 Chain B Binding Site BS02

Receptor Information
>5i50 Chain B (length=96) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FQGAMATEENVKRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKV
VILKKATAYILSVQAETQKLISEIDLLRKQNEQLKHKLEQLRNSCA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5i50 OmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors.
Resolution2.701 Å
Binding residue
(original residue number in PDB)		H12 E16 R19
Binding residue
(residue number reindexed from 1)		H16 E20 R23
Binding affinityPDBbind-CN: Kd=391nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0046983 protein dimerization activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:5i50, PDBe:5i50, PDBj:5i50
PDBsum5i50
PubMed27748763
UniProtP01106|MYC_HUMAN Myc proto-oncogene protein (Gene Name=MYC)

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