Structure of PDB 5gwz Chain B Binding Site BS02

Receptor Information
>5gwz Chain B (length=299) Species: 229032 (Porcine epidemic diarrhea virus CV777) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GLRKMAQPSGVVEKCIVRVCYGNMALNGLWLGDIVMCPRHVIASSTTSTI
DYDYALSVLRLHNFSISSGNVFLGVVSATMRGALLQIKVNQNNVHTPKYT
YRTVRPGESFNILACYDGAAAGVYGVNMRSNYTIRGSFINGACGSPGYNI
NNGTVEFCYLHQLELGSGCHVGSDLDGVMYGGYEDQPTLQVEGASSLFTE
NVLAFLYAALINGSTWWLSSSRIAVDRFNEWAVHNGMTTVGNTDCFSILA
AKTGVDVQRLLASIQSLHKNFGGKQILGHTSLTDEFTTGEVVRQMYGVN
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5gwz Michael Acceptor-Based Peptidomimetic Inhibitor of Main Protease from Porcine Epidemic Diarrhea Virus
Resolution2.444 Å
Binding residue
(original residue number in PDB)		M25 A26
Binding residue
(residue number reindexed from 1)		M24 A25
Enzymatic activity
Catalytic site (original residue number in PDB) H41 G142 C144
Catalytic site (residue number reindexed from 1) H40 G141 C143
Enzyme Commision number 2.7.7.50: mRNA guanylyltransferase.
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
Biological Process
GO:0019082 viral protein processing

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Molecular Function
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Biological Process
External links
PDB RCSB:5gwz, PDBe:5gwz, PDBj:5gwz
PDBsum5gwz
PubMed28287727
UniProtP0C6V6|R1A_PEDV7 Replicase polyprotein 1a (Gene Name=1a)

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