Structure of PDB 5g10 Chain B Binding Site BS02

Receptor Information
>5g10 Chain B (length=376) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TRRTAFFFDELCLWHAAGPHALTLPVGGWVQPPAAAGHAESPETKRRLKS
LLDVSGLTARLQLRSAPPASDEDLLRVHPAHYLERFKALSDAGGGSLGQD
APIGPGSYEIARLSAGLAIAALDAVLAGEADNAYSLSRPPGHHCLPDQAM
GFCFFANIAVAIEAAKARHGVERVAVLDWDVHHGNGTQAIYYRRDDVLSI
SLHQDGCFPPGYSGAEDIGEDRGRGFNLNVPLLPGGGHDAYMQAMQRIVL
PALERFRPQLIVVASGFDANAVDPLARMQLHSDSFRAMTAMVRDAAERHA
GGRLVVVHEGGYSEAYVPFCGLAVIEELSGVRSAVRDPLRDFIELQQPNA
AFRDFQRQRLEELAAQFGLCPAQPLQ
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5g10 Chain B Residue 1378 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5g10 Crystal Structure of a Histone Deacetylase Homologue from Pseudomonas aeruginosa.
Resolution1.71 Å
Binding residue
(original residue number in PDB)		D181 H183 D269
Binding residue
(residue number reindexed from 1)		D180 H182 D268
Annotation score1
Enzymatic activity
Enzyme Commision number 3.5.1.-
Gene Ontology
Molecular Function
GO:0004407 histone deacetylase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0040029 epigenetic regulation of gene expression

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5g10, PDBe:5g10, PDBj:5g10
PDBsum5g10
PubMed27951649
UniProtQ9HXM1|HDAH_PSEAE Histone deacetylase-like amidohydrolase (Gene Name=PA3774)

[Back to BioLiP]