Structure of PDB 5fym Chain B Binding Site BS02

Receptor Information
>5fym Chain B (length=446) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DKLNPPTPSIYLENKRDAFFPPLHQFCTNPKNPVTVIRGLAGALKLDLGL
FSTKTLVEANNEHMVEVRTQLLQPADENWDPTGTKKIWRCESNRSHTTIA
KYAQYQASSFQESLREENEPFKTIKFGTNIDLSDNKKWKLQLHELTKLPA
FARVVSAGNLLTHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNIN
IGPGDCEWFVVPEDYWGVLNDFCEKNNLNFLMSSWWPNLEDLYEANVPVY
RFIQRPGDLVWINAGTVHWVQAVGWCNNIAWNVGPLTACQYKLAVERYEW
NKLKSVKSPVPMVHLSWNMARNIKVSDPKLFEMIKYCLLKILKQYQTLRE
ALVAAGKEVIWHGRTNDEPAHYCSICEVEVFNLLFVTNESNTQKTYIVHC
HDCARKTSKSLENFVVLEQYKMEDLIQVYDQFTLALSLSSSSAENL
Ligand information
Ligand ID2HG
InChIInChI=1S/C5H8O5/c6-3(5(9)10)1-2-4(7)8/h3,6H,1-2H2,(H,7,8)(H,9,10)/t3-/m1/s1
InChIKeyHWXBTNAVRSUOJR-GSVOUGTGSA-N
SMILES
SoftwareSMILES
CACTVS 3.370O[CH](CCC(O)=O)C(O)=O
ACDLabs 12.01O=C(O)CCC(O)C(=O)O
OpenEye OEToolkits 1.7.0C(CC(=O)O)C(C(=O)O)O
OpenEye OEToolkits 1.7.0C(CC(=O)O)[C@H](C(=O)O)O
CACTVS 3.370O[C@H](CCC(O)=O)C(O)=O
FormulaC5 H8 O5
Name(2R)-2-hydroxypentanedioic acid
ChEMBLCHEMBL1614745
DrugBank
ZINCZINC000000402968
PDB chain5fym Chain B Residue 2274 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5fym Crystal Structure of Jmjc Domain of Human Histone Demethylase Uty in Complex with D-2- Hydroxyglutarate
Resolution2.0 Å
Binding residue
(original residue number in PDB)		K1005 T1011 H1014 S1022 N1024 W1034
Binding residue
(residue number reindexed from 1)		K179 T185 H188 S196 N198 W208
Annotation score2
Enzymatic activity
Enzyme Commision number 1.14.11.68: [histone H3]-trimethyl-L-lysine(27) demethylase.
External links
PDB RCSB:5fym, PDBe:5fym, PDBj:5fym
PDBsum5fym
PubMed
UniProtO14607|UTY_HUMAN Histone demethylase UTY (Gene Name=UTY)

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