Structure of PDB 5f0p Chain B Binding Site BS02

Receptor Information
>5f0p Chain B (length=293) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FGPICEIDIVLNDGETRKMAEMKTEDGKVEKHYLFYDGESVSGKVNLAFK
QPGKRLEHQGIRIEFVGQIELFNDKSNTHEFVNLVKELALPGELTQSRSY
DFEFMQVEKPYESYIGANVRLRYFLKVTIVRRLTDLVKEYDLIVHQLATY
PDVNNSIKMEVGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLLVRIKIQHM
ELQLIKKEITGIGPSTTTETETIAKYEIMDGAPVKGESIPIRLFLAGYDP
TPTMRDVNKKFSVRYFLNLVLVDEEDRRYFKQQEIILWRKAPE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5f0p Chain B Residue 415 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5f0p Structural Mechanism for Cargo Recognition by the Retromer Complex.
Resolution2.78 Å
Binding residue
(original residue number in PDB)		E167 H175
Binding residue
(residue number reindexed from 1)		E160 H168
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0006886 intracellular protein transport
GO:0015031 protein transport
GO:0016241 regulation of macroautophagy
GO:0032456 endocytic recycling
GO:0042147 retrograde transport, endosome to Golgi
Cellular Component
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005768 endosome
GO:0005769 early endosome
GO:0005829 cytosol
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0030904 retromer complex
GO:0030906 retromer, cargo-selective complex
GO:0031982 vesicle
GO:0097422 tubular endosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5f0p, PDBe:5f0p, PDBj:5f0p
PDBsum5f0p
PubMed27889239
UniProtO75436|VP26A_HUMAN Vacuolar protein sorting-associated protein 26A (Gene Name=VPS26A)

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