Structure of PDB 5d1k Chain B Binding Site BS02

Receptor Information
>5d1k Chain B (length=110) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NIPHGQCVICLYGFQEKEAFTKTPCYHYFHCHCLARYIQHMEQELKAQGG
VQCPVCREPLVYDLASLKAAPEPQQPMELYQPSAESLRQQEERKRLYQRQ
QERGGIIDLE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5d1k Chain B Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5d1k Insights into Ubiquitination from the Unique Clamp-like Binding of the RING E3 AO7 to the E2 UbcH5B.
Resolution1.78 Å
Binding residue
(original residue number in PDB)		C153 H155 C198 C201
Binding residue
(residue number reindexed from 1)		C25 H27 C53 C56
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0061630 ubiquitin protein ligase activity

View graph for
Molecular Function
External links
PDB RCSB:5d1k, PDBe:5d1k, PDBj:5d1k
PDBsum5d1k
PubMed26475854
UniProtQ96BH1|RNF25_HUMAN E3 ubiquitin-protein ligase RNF25 (Gene Name=RNF25)

[Back to BioLiP]