Structure of PDB 5cmb Chain B Binding Site BS02

Receptor Information
>5cmb Chain B (length=255) Species: 27923 (Mnemiopsis leidyi) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSKNLIGRHLRLGSVEEQPFMFFATEGCEGNDCWSGMVNDMVVKLSEDLG
FTYEYIQPDDRKFGALNKTTNEWNGMIRDLLDDKTDMIAIDLSTNSARKS
AIDYSFPFMDAGIKAVVKGEGTTLNQVLELLDQDKYKWGVIGSKHPETLL
KTHRDSRYSRLVDEGVELKDLNHAIETLRGGLFVFIDEGPVLAHNLISDC
DVFSVGEEFQSFEYAFGLPKDSPYKSLIDSHLLKFREEGFIDILWEKWSS
GNSVC
Ligand information
Ligand IDGLY
InChIInChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
InChIKeyDHMQDGOQFOQNFH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C(=O)O)N
CACTVS 3.341NCC(O)=O
ACDLabs 10.04O=C(O)CN
FormulaC2 H5 N O2
NameGLYCINE
ChEMBLCHEMBL773
DrugBankDB00145
ZINCZINC000004658552
PDB chain5cmb Chain B Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5cmb Molecular lock regulates binding of glycine to a primitive NMDA receptor.
Resolution1.34 Å
Binding residue
(original residue number in PDB)		F63 D91 L92 S93 R98 K144 H145 E188
Binding residue
(residue number reindexed from 1)		F63 D91 L92 S93 R98 K144 H145 E188
Annotation score4
Binding affinityMOAD: Kd=28.3nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
GO:0046872 metal ion binding
Biological Process
GO:0034220 monoatomic ion transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5cmb, PDBe:5cmb, PDBj:5cmb
PDBsum5cmb
PubMed27791085
UniProtA0A0R4I973

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