Structure of PDB 5bud Chain B Binding Site BS02

Receptor Information
>5bud Chain B (length=387) Species: 237561 (Candida albicans SC5314) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MAKSLPLNSRSKTTKQPRELFSYARDIDGKYVYDDPENSLSYYYLPDSTI
DTGIDLQGGYSKFKKIPDEQNLADFNSLLKAIIKYETSEGKKISSDIITF
REIMTKILSLPYNLTDPIDLYVVPFDGQLFIKSDDELDMKRRKEQEVRMK
QTNTVERYDYMKRCEYVGYKFETIATIPKPWSQVSRSQIENRNKKVVNNY
EQYLSVIRTGIGNVKLVLAGEIDCCWDYLPDEQNKKLNHYVELKTSRIIE
NNSQVVSFEQKLFKAWCQCFLMGVTKIIYGFRDNNLILKNVELFNTEEIP
ILIKNNPLTNAATEKKINCTNALKWYGAVVDWLNTTVDKKDEIKSYRLKY
DPVRKSFTLSETDSETNEKLRNGQLLTPEFTEWRQSL
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain5bud Chain B Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5bud Structural and biochemical studies of the distinct activity profiles of Rai1 enzymes.
Resolution1.99 Å
Binding residue
(original residue number in PDB)		D225 E244 L245
Binding residue
(residue number reindexed from 1)		D223 E242 L243
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.1.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0004518 nuclease activity
GO:0030234 enzyme regulator activity
GO:0034353 mRNA 5'-diphosphatase activity
GO:0046872 metal ion binding
GO:0110152 RNA NAD+-cap (NAD+-forming) hydrolase activity
GO:1990174 phosphodiesterase decapping endonuclease activity
Biological Process
GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000956 nuclear-transcribed mRNA catabolic process
GO:0006397 mRNA processing
GO:0030846 termination of RNA polymerase II transcription, poly(A)-coupled
GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA
GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process
GO:0110155 NAD-cap decapping
GO:1904595 positive regulation of termination of RNA polymerase II transcription
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0090730 Las1 complex
GO:0110103 RNA polymerase II termination complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5bud, PDBe:5bud, PDBj:5bud
PDBsum5bud
PubMed26101253
UniProtQ5AAT0|DXO_CANAL Decapping nuclease RAI1 (Gene Name=RAI1)

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