Structure of PDB 5btr Chain B Binding Site BS02

Receptor Information

>5btr Chain B (length=366) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SRDNLLFGDEIITNGSDWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPE
TIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQESKKIIV
LTGAGVSVSSGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRP
FFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQR
IIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMK
PEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHE
VPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLSSNITEQY
LFLPPNRYIFHGAEVY

Ligand information

>5btr Chain F (length=4) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

RHKA

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5btr Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol
Resolution	3.2 Å
Binding residue (original residue number in PDB)	D150 P180
Binding residue (residue number reindexed from 1)	D9 P22

Enzymatic activity

Catalytic site (original residue number in PDB)	P271 D272 F273 R274 N346 D348 H363
Catalytic site (residue number reindexed from 1)	P113 D114 F115 R116 N188 D190 H205
Enzyme Commision number	2.3.1.- 2.3.1.286: protein acetyllysine N-acetyltransferase.

Gene Ontology

	Molecular Function
GO:0070403	NAD+ binding

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Molecular Function

External links

PDB	RCSB:5btr, PDBe:5btr, PDBj:5btr
PDBsum	5btr
PubMed	26109052
UniProt	Q96EB6\|SIR1_HUMAN NAD-dependent protein deacetylase sirtuin-1 (Gene Name=SIRT1)

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