Structure of PDB 5ah4 Chain B Binding Site BS02

Receptor Information
>5ah4 Chain B (length=380) Species: 1772 (Mycolicibacterium smegmatis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TDLKFRVVREDFADAVAWVARSLPTRIPVLAGVLLTGTDEGLTISGFDYE
VSAEVKVSAEIASAGSVLVSGRLLSDITKALPAKPVEVSVEGTRVSLTCG
SARFSLPTLAVEDYPALPALPEETGVIASDLFAEAIGQVAVAAGRDDTLP
MLTGIRVEISGESVVLAATDRFRLAVRELTWVTTAGDVEAAVLVPAKTLA
EAAKAGTNQVHLALGSGASVGKDGLLGIRSEGKRSTTRLLDAEFPKFRQL
LPAEHTAVATIGVAELTEAIKRVALVADRGAQIRMEFSDDTLKLSAGADD
VGRAEEDLPVDFAGEPLTIAFNPTYLTDGLGSLHSERVTFGFTTPSRPAV
LRPAGEDGGSGPFPAAKTDYVYLLMPVRLP
Ligand information
Receptor-Ligand Complex Structure
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PDB5ah4 Antibiotics. Targeting Dnan for Tuberculosis Therapy Using Novel Griselimycins.
Resolution2.313 Å
Binding residue
(original residue number in PDB)		M161 R181 F182 R183 E255 L262 M391 P392 R394
Binding residue
(residue number reindexed from 1)		M151 R171 F172 R173 E243 L250 M375 P376 R378
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0008408 3'-5' exonuclease activity
Biological Process
GO:0006260 DNA replication
GO:0006271 DNA strand elongation involved in DNA replication
GO:0046677 response to antibiotic
GO:0071897 DNA biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0009360 DNA polymerase III complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5ah4, PDBe:5ah4, PDBj:5ah4
PDBsum5ah4
PubMed26045430
UniProtA0QND6|DPO3B_MYCS2 Beta sliding clamp (Gene Name=dnaN)

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