Structure of PDB 5ah2 Chain B Binding Site BS02

Receptor Information
>5ah2 Chain B (length=377) Species: 1772 (Mycolicibacterium smegmatis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TDLKFRVVREDFADAVAWVARSLPTPTIPVLAGVLLTGTDEGLTISGFDY
EVSAEVKVSAEIASAGSVLVSGRLLSDITKALPAKPVEVSVEGTRVSLTC
GSARFSLPTLAVEDYPALPALPEETGVIASDLFAEAIGQVAVAAGRLPML
TGIRVEISGESVVLAATDRFRLAVRELTWVTTAGDVEAAVLVPAKTLAEA
AKAGTDGNQVHLALGSGASVGKDGLLGIRSEGKRSTTRLLDAEFPKFRQL
LPAEHTAVATIGVAELTEAIKRVALVADRGAQIRMEFSDDTLKLSAGADD
VGRAEEDLPVDFAGEPLTIAFNPTYLTDGLGSLHSERVTFGFTTPSRPAV
LRPAGGSGPFPAAKTDYVYLLMPVRLP
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5ah2 Antibiotics. Targeting Dnan for Tuberculosis Therapy Using Novel Griselimycins.
Resolution2.129 Å
Binding residue
(original residue number in PDB)		I37 D123
Binding residue
(residue number reindexed from 1)		I28 D114
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0008408 3'-5' exonuclease activity
Biological Process
GO:0006260 DNA replication
GO:0006271 DNA strand elongation involved in DNA replication
GO:0046677 response to antibiotic
GO:0071897 DNA biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0009360 DNA polymerase III complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5ah2, PDBe:5ah2, PDBj:5ah2
PDBsum5ah2
PubMed26045430
UniProtA0QND6|DPO3B_MYCS2 Beta sliding clamp (Gene Name=dnaN)

[Back to BioLiP]