Structure of PDB 4zpk Chain B Binding Site BS02

Receptor Information

>4zpk Chain B (length=321) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KRSSSELRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIM
RLAISFLRTHKLLSSVCSENESEAEADQQMDNLYLKALEGFIAVVTQDGD
MIFLSENISKFMGLTQVELTGHSIFDFTHPCDHEEIRENLTLSTERDFFM
RMKCTVTNRGRTVNLKSATWKVLHCTGQVRVYNLSCLIIMCEPIQHPSHM
DIPLDSKTFLSRHSMDMKFTYCDDRILELIGYHPEELLGRSAYEFYHALD
SENMTKSHQNLCTKGQVVSGQYRMLAKHGGYVWLETQGTVIYNLQPQCIM
CVNYVLSEIKNDVVFSMDQTE

Ligand information

>4zpk Chain D (length=21) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

cacgacccgcacgtacgcagc

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	4zpk Structural integration in hypoxia-inducible factors.
Resolution	3.6 Å
Binding residue (original residue number in PDB)	K16 S19 R20 R24 R27 K53
Binding residue (residue number reindexed from 1)	K9 S12 R13 R17 R20 K46
Binding affinity	PDBbind-CN: Kd=45nM

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003700	DNA-binding transcription factor activity
GO:0046983	protein dimerization activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription

	Cellular Component
GO:0005634	nucleus
GO:0005667	transcription regulator complex
GO:0005737	cytoplasm

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:4zpk, PDBe:4zpk, PDBj:4zpk
PDBsum	4zpk
PubMed	26245371
UniProt	P97481\|EPAS1_MOUSE Endothelial PAS domain-containing protein 1 (Gene Name=Epas1)

[Back to BioLiP]