Structure of PDB 4z53 Chain B Binding Site BS02

Receptor Information
>4z53 Chain B (length=695) Species: 170187 (Streptococcus pneumoniae TIGR4) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAK
AKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDADTDGAHI
QTLLLTFFYRYMRPLVEAGHVYIALPPLYKMAYAWTDGELEELRKQLQRY
KGLGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGDKVEPRR
KWIEDNVKFTLEENIQNMSLEDIMGERFGRYSKYIIQDRALPDIRDGLKP
VQRRILYSMNKDSNTFDKSYRKSAKSVGNIMGNFHPHGDSSIYDAMVRMS
QNWKNREILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKKTV
PFAWNFDDTEKEPTVLPAAFPNLLVNGSTGISAGYATDIPPHNLAEVIDA
AVYMIDHPTAKIDKLMEFLPGPDFPTGAIIQGRDEIKKAYETGKGRVVVR
SKTEIEKLKGGKEQIVITEIPYEINKANLVKKIDDVRVNNKVAGIAEVRD
ESDRDGLRIAIELKKDANTELVLNYLFKYTDLQINYNFNMVAIDNFTPRQ
VGIVPILSSYIAHRREVILARSRFDKEKAEKRLHIVEGLIRVISILDEVI
ALIRASENKADAKENLKVSYDFTEEQAEAIVTLQLYRLTNTDVVVLQEEE
AELREKIAMLAAIIGDERTMYNLMKKELREVKKKFATPRLSSLED
Ligand information
Receptor-Ligand Complex Structure
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PDB4z53 Structural studies of the drug-stabilized cleavage complexes of topoisomerase IV and gyrase from Streptococcus pneumoniae
Resolution3.26 Å
Binding residue
(original residue number in PDB)		E433 G457 D510 R1028 K1038 H1074 H1076 S1080 R1087 T1168 I1170
Binding residue
(residue number reindexed from 1)		E19 G43 D96 R239 K249 H285 H287 S291 R298 T379 I381
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change
Cellular Component
GO:0005694 chromosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4z53, PDBe:4z53, PDBj:4z53
PDBsum4z53
PubMed
UniProtP72525|PARC_STRPN DNA topoisomerase 4 subunit A (Gene Name=parC);
Q59961|PARE_STRPN DNA topoisomerase 4 subunit B (Gene Name=parE)

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