Structure of PDB 4z2c Chain B Binding Site BS02

Receptor Information
>4z2c Chain B (length=482) Species: 1313 (Streptococcus pneumoniae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QDKNLVNVNLTKEMKASFIDYAMSVIVARALPDVRDGLKPVHRRILYGMN
ELGVTPDKPHKKSARITGDVMGKYHPHGDSSIYEAMVRMAQWWSYRYMLV
DGHGNFGSMDGDSAAAQRYTEARMSKIALEMLRDINKNTVDFVDNYDANE
REPLVLPARFPNLLVNGATGIAVGMATNIPPHNLGETIDAVKLVMDNPEV
TTKDLMEVLPGPDFPTGALVMGKSGIHKAYETGKGSIVLRSRTEIETTKT
GRERIVVTEFPYMVNKTKVHEHIVRLVQEKRIEGITAVRDESNREGVFVI
EVKRDSANVILNNLFKMTMQTNFGFNMLAIQNGIPKILSLRQILDAYIEH
QKEVVVRRTRFDKEKAEARAHILEGLLIALDHIDEVIRIIRASETDAEAQ
AELMSKFKLSERQSQAILDMRLRRLTGLERDKIQSEYDDLLALIADLADI
LAKPERVSQIIKDELDEVKRKFSDKRRTELMV
Ligand information
Receptor-Ligand Complex Structure
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PDB4z2c Structural studies of the drug-stabilized cleavage complexes of topoisomerase IV and gyrase from Streptococcus pneumoniae
Resolution3.19 Å
Binding residue
(original residue number in PDB)		R30 K40 H43 H76 H78 R89 I172
Binding residue
(residue number reindexed from 1)		R29 K39 H42 H75 H77 R88 I171
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:4z2c, PDBe:4z2c, PDBj:4z2c
PDBsum4z2c
PubMed
UniProtQ8DPM2|GYRA_STRR6 DNA gyrase subunit A (Gene Name=gyrA)

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