Structure of PDB 4yki Chain B Binding Site BS02

Receptor Information

>4yki Chain B (length=255) Species: 27923 (Mnemiopsis leidyi) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GSKNLIGRHLRLGSVEEQPFMFFATEGCEGNDCWSGMVNDMVVKLSEDLG
FTYEYIQPDDRKFGALNKTTNEWNGMIRDLLDDKTDMIAIDLSTNSARKS
AIDYSFPFMDAGIKAVVKGEGTTLNQVLELLDQDKYKWGVIGSRHPETLL
KTHRDSRYSRLVDEGVELKDLNHAIETLRGGLFVFIDEGPVLAHNLISDC
DVFSVGEEFQSFEYAFGLPKDSPYKSLIDSHLLKFREEGFIDILWEKWSS
GNSVC

Ligand information

Ligand ID

GLY

InChI

InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)

InChIKey

DHMQDGOQFOQNFH-UHFFFAOYSA-N

SMILES

Software	SMILES
OpenEye OEToolkits 1.5.0	C(C(=O)O)N
CACTVS 3.341	NCC(O)=O
ACDLabs 10.04	O=C(O)CN

Formula

C2 H5 N O2

Name

GLYCINE

PDB chain

4yki Chain B Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4yki Glycine activated ion channel subunits encoded by ctenophore glutamate receptor genes.
Resolution	1.21 Å
Binding residue (original residue number in PDB)	F63 D91 S93 R98 R144 H145 E188
Binding residue (residue number reindexed from 1)	F63 D91 S93 R98 R144 H145 E188
Annotation score	4
Binding affinity	MOAD: Kd=2.7nM

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0015276	ligand-gated monoatomic ion channel activity
GO:0046872	metal ion binding

	Biological Process
GO:0034220	monoatomic ion transmembrane transport

	Cellular Component
GO:0016020	membrane

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External links

PDB	RCSB:4yki, PDBe:4yki, PDBj:4yki
PDBsum	4yki
PubMed	26460032
UniProt	A0A0R4I973

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