Structure of PDB 4y5w Chain B Binding Site BS02

Receptor Information
>4y5w Chain B (length=477) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KFKTGLRRLQHRVGEIHLLREALQKALAMLLQETTGELEAAKALVLKRIQ
IWKRQQQLAGNGAPFEESLAPLQERCESLVDIYSQLQQEVGAAGTRASLT
GRLDEVLRTLVTSCFLVEKQPPQVLKTQTKFQAGVRFLLGLRFLGAPAKP
PLVRADMVTEKQARETGEIINNTVPLENSIPGNCCSALFKNLLLKKIKRC
ERKGTESVTEEKCAVLFSASFTLGPPIQLQALSLPLVVIVHGNQDNNAKA
TILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTNRGLLPEHF
LFLAQKIFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDL
TKRCLRSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIA
HVIRGQDGSPQIENIQPFSAKDLSIRSLGDRIRDLAQLKNLYPKKPKDEA
FRSHYKPEQMGKDGRGYVPATIKMTVE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4y5w Structural basis for DNA recognition by STAT6
Resolution3.104 Å
Binding residue
(original residue number in PDB)		R370 V379 V414
Binding residue
(residue number reindexed from 1)		R199 V208 V240
Binding affinityPDBbind-CN: Kd=79nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0007165 signal transduction

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4y5w, PDBe:4y5w, PDBj:4y5w
PDBsum4y5w
PubMed27803324
UniProtP42226|STAT6_HUMAN Signal transducer and activator of transcription 6 (Gene Name=STAT6)

[Back to BioLiP]