Structure of PDB 4xq8 Chain B Binding Site BS02

Receptor Information
>4xq8 Chain B (length=247) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SESVPVLELFSNIWGAGTKTAQMWYQQGFRSLEDIRSQASLTTQQAIGLK
HYSDFLERMPREEATEIEQTVQKAAQAFNSGLLCVACGSYRRGKATCGDV
DVLITHPDGRSHRGIFSRLLDSLRQEGFLTDDLVSQEENGQQQKYLGVCR
LPGPGRRHRRLDIIVVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLS
EHALSTAVVRNTHGCKVGPGRVLPTPTEKDVFRLLGLPYREPAERDW
Ligand information
Receptor-Ligand Complex Structure
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PDB4xq8 Structural Mechanism for the Fidelity Modulation of DNA Polymerase lambda
Resolution2.798 Å
Binding residue
(original residue number in PDB)		Q372 V462 E466 N467 R514 R517 A518 K521 L527 S528 E529
Binding residue
(residue number reindexed from 1)		Q44 V134 E138 N139 R186 R189 A190 K193 L199 S200 E201
Enzymatic activity
Catalytic site (original residue number in PDB) D427 D429 D490
Catalytic site (residue number reindexed from 1) D99 D101 D162
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
4.2.99.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4xq8, PDBe:4xq8, PDBj:4xq8
PDBsum4xq8
PubMed26836966
UniProtQ9UGP5|DPOLL_HUMAN DNA polymerase lambda (Gene Name=POLL)

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