Structure of PDB 4xdj Chain B Binding Site BS02

Receptor Information
>4xdj Chain B (length=243) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KWKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRDHV
CVSPQELETLIQHALDADNAGVSPIGSHWDLGSAFFFAGTVITTIGYGNI
APSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSIARVEKVFSQ
TKIRVISTILFILAGCIVFVTIPAVIFKYIEGWTALESIYFVVVTLTTVG
FGDFVAGGREWYKPLVWFWILVGLAYFAAVLSMIGDWLRVLSK
Ligand information
Ligand IDK
InChIInChI=1S/K/q+1
InChIKeyNPYPAHLBTDXSSS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[K+]
FormulaK
NamePOTASSIUM ION
ChEMBLCHEMBL1233793
DrugBankDB01345
ZINC
PDB chain4xdj Chain A Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4xdj K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		T172 I173 G174 T281 V282
Binding residue
(residue number reindexed from 1)		T94 I95 G96 T198 V199
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005267 potassium channel activity
Biological Process
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4xdj, PDBe:4xdj, PDBj:4xdj
PDBsum4xdj
PubMed25766236
UniProtP57789|KCNKA_HUMAN Potassium channel subfamily K member 10 (Gene Name=KCNK10)

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