Structure of PDB 4wrn Chain B Binding Site BS02

Receptor Information
>4wrn Chain B (length=663) Species: 9606,83334 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GHHHHHHKTEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKL
EEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPAAAFQDKLYPFT
WDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKG
KSALMFNLQEPYFTWPLIAADGGYAFKYAAGKYDIKDVGVDNAGAKAGLT
FLVDLIKNKHMNADTDYSIAEHAFNHGETAMTINGPWAWSNIDTSAVNYG
VTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAV
NKDKPLGAVALKSYEEELVKDPRVAATMENAQKGEIMPNIPQMSAFWYAV
RTAVINAASGRQTVDAALAAAQTNAAITDISLLEHRLECGANDMKVSLGK
CQLKSLGFDKVFMYLSDSRCSGFNDRDNRDWVSVVTPARDGPCGTVLTRN
ETHATYSNTLYLADEIIIRDLNIKINFACSYPLDMKVSLKTALQPMVSAL
NIRVGGTGMFTVRMALFQTPSYTQPYQGSSVTLSTEAFLYVGTMLDGGDL
SRFALLMTNCYATPSSQATDPLKYFIIQDRCPHTRDSTIQVVENGESSQG
RFSVQMFRFAGNYDLVYLHCEVYLCDTMNEKCKPTCSGTAFASGSVIDQS
RVLNLGPITRKGV
Ligand information
Ligand IDGLC
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6+/m1/s1
InChIKeyWQZGKKKJIJFFOK-DVKNGEFBSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C1C(C(C(C(O1)O)O)O)O)O
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O)O)O)O)O
CACTVS 3.341OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
CACTVS 3.341OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O
ACDLabs 10.04OC1C(O)C(OC(O)C1O)CO
FormulaC6 H12 O6
Namealpha-D-glucopyranose;
alpha-D-glucose;
D-glucose;
glucose
ChEMBLCHEMBL423707
DrugBank
ZINCZINC000003861213
PDB chain4wrn Chain D Residue 2 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4wrn A structured interdomain linker directs self-polymerization of human uromodulin.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		W86 D89 R90 E177 Y179 W364 R368
Binding residue
(residue number reindexed from 1)		W69 D72 R73 E160 Y162 W347 R351
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0015144 carbohydrate transmembrane transporter activity
GO:1901982 maltose binding
Biological Process
GO:0008643 carbohydrate transport
GO:0015768 maltose transport
GO:0034219 carbohydrate transmembrane transport
GO:0042956 maltodextrin transmembrane transport
GO:0055085 transmembrane transport
Cellular Component
GO:0030288 outer membrane-bounded periplasmic space
GO:0042597 periplasmic space
GO:0055052 ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4wrn, PDBe:4wrn, PDBj:4wrn
PDBsum4wrn
PubMed26811476
UniProtP07911|UROM_HUMAN Uromodulin (Gene Name=UMOD);
P0AEY0|MALE_ECO57 Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE)

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