Structure of PDB 4uee Chain B Binding Site BS02

Receptor Information

>4uee Chain B (length=306) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

STDTFNYATYHTLEEIYDFLDLLVAENPHLVSKIQIGNTYEGRPIYVLKF
STGGSKRPAIWIDTGIHSREWVTQASGVWFAKKITQDYGQDAAFTAILDT
LDIFLEIVTNPDGFAFTHSTNRMWRKTRSHTAGSLCIGVDPNRNWDAGFG
LSGASSNPCSETYHGKFANSEVEVKSIVDFVKDHGNIKAFISIHSYSQLL
MYPYGYKTEPVPDQDELDQLSKAAVTALASLYGTKFNYGSIIKAIYQASG
STIDWTYSQGIKYSFTFELRDTGRYGFLLPASQIIPTAKETWLALLTIME
HTLNHP

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

4uee Chain B Residue 1310 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4uee Crystal Structure of the Human Carboxypeptidase A1 in Complex with Phosphinic Inhibitors
Resolution	2.27 Å
Binding residue (original residue number in PDB)	H69 E72 H196
Binding residue (residue number reindexed from 1)	H67 E70 H194
Annotation score	1

Enzymatic activity

Catalytic site (original residue number in PDB)	H69 E72 R127 H196 E270
Catalytic site (residue number reindexed from 1)	H67 E70 R125 H194 E268
Enzyme Commision number	3.4.17.1: carboxypeptidase A.

Gene Ontology

	Molecular Function
GO:0004181	metallocarboxypeptidase activity
GO:0008270	zinc ion binding

	Biological Process
GO:0006508	proteolysis

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Molecular Function

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Biological Process

External links

PDB	RCSB:4uee, PDBe:4uee, PDBj:4uee
PDBsum	4uee
PubMed
UniProt	P15085\|CBPA1_HUMAN Carboxypeptidase A1 (Gene Name=CPA1)

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