Structure of PDB 4tmw Chain B Binding Site BS02

Receptor Information
>4tmw Chain B (length=345) Species: 209285 (Thermochaetoides thermophila) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GHMNKDNLRSPICCILGHVDTGKTKLLDKIRQTNVQEGEAGGITQQIGAT
YFPVEAIKQKTAVVNKDGKFEFKVPGLLIIDTPGHESFSNLRSRGSSLCN
IAILVVDIMHGLEPQTIESLRLLRERKTPFVVALNKIDRLYGWKKIENNG
FRESFALQNKAVQNEFRNRLDQVKLQFAEQGFNSELFYENKNFARYVSLV
PTSAHTGEGIPDMLKLIVQLCQERMASSLMYLSELQATVLEVKAIEGFGV
TIDVILSNGILREGDRIVLCGLEGPIKTNIRALLTPAPMRELRIKGQYIH
HKEVKAAQGVKISAPGLEGAIAGSRLLVVGPDDDEEELEEEVESD
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain4tmw Chain B Residue 903 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4tmw A monovalent cation acts as structural and catalytic cofactor in translational GTPases.
Resolution1.55 Å
Binding residue
(original residue number in PDB)		T537 T557
Binding residue
(residue number reindexed from 1)		T24 T44
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.5.3: protein-synthesizing GTPase.
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:4tmw, PDBe:4tmw, PDBj:4tmw
PDBsum4tmw
PubMed25225612
UniProtG0S8G9|IF2P_CHATD Eukaryotic translation initiation factor 5B (Gene Name=CTHT_0029840)

[Back to BioLiP]