Structure of PDB 4s18 Chain B Binding Site BS02

Receptor Information
>4s18 Chain B (length=122) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KETAAAKFERQHMDSSTASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLA
DVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQA
NKHIIVACEGNPYVPVHFDASV
Ligand information
Ligand ID1PT
InChIInChI=1S/C6H14N2.Pt/c7-5-3-1-2-4-6(5)8;/h5-6H,1-4,7-8H2;/q;+2/t5-,6-;/m1./s1
InChIKeySGLJYTWMWIAGEU-KGZKBUQUSA-N
SMILES
SoftwareSMILES
ACDLabs 12.01[Pt+2]1NC2C(N1)CCCC2
OpenEye OEToolkits 1.7.6C1CCC2C(C1)[NH2][Pt+2][NH2]2
CACTVS 3.385[Pt++]|1|N[CH]2CCCC[CH]2N|1
CACTVS 3.385[Pt++]|1|N[C@@H]2CCCC[C@H]2N|1
OpenEye OEToolkits 1.7.6C1CC[C@@H]2[C@@H](C1)[NH2][Pt+2][NH2]2
FormulaC6 H14 N2 Pt
NameCYCLOHEXANE-1(R),2(R)-DIAMINE-PLATINUM(II);
OXALIPLATIN
ChEMBL
DrugBank
ZINC
PDB chain4s18 Chain B Residue 202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4s18 Interactions of carboplatin and oxaliplatin with proteins: Insights from X-ray structures and mass spectrometry studies of their ribonuclease A adducts.
Resolution2.27 Å
Binding residue
(original residue number in PDB)		D14 Y25 M29
Binding residue
(residue number reindexed from 1)		D14 Y23 M27
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H12 K41 H119 F120 D121
Catalytic site (residue number reindexed from 1) H12 K39 H117 F118 D119
Enzyme Commision number 4.6.1.18: pancreatic ribonuclease.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004519 endonuclease activity
GO:0004522 ribonuclease A activity
GO:0004540 RNA nuclease activity
GO:0005515 protein binding
GO:0016829 lyase activity
Biological Process
GO:0050830 defense response to Gram-positive bacterium
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4s18, PDBe:4s18, PDBj:4s18
PDBsum4s18
PubMed26239545
UniProtP61823|RNAS1_BOVIN Ribonuclease pancreatic (Gene Name=RNASE1)

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