Structure of PDB 4rzb Chain B Binding Site BS02

Receptor Information
>4rzb Chain B (length=451) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SAIFAERALLPEGWARNVRFEISADGVLAEIRPDANADGAERLGGAVLPG
MPNLHSHAFQRAMAGLAEVAGNPNDSFWTWRELMYRMVARLSPEQIEVIA
CQLYIEMLKAGYTAVAEFHYVHHDLDGRSYADPAELSLRISRAASAAGIG
LTLLPVLYSHAGFGGQPASEGQRRFINGSEAYLELLQRLRAPLEAAGHSL
GLCFHSLRAVTPQQIATVLAAGHDDLPVHIHIAEQQKEVDDCQAWSGRRP
LQWLYENVAVDQRWCLVHATHADPAEVAAMARSGAVAGLCLSTEANLGDG
IFPATDFLAQGGRLGIGSDSHVSLSVVEELRWLEYGQRLRDRKRNRLYRD
DQPMIGRTLYDAALAGGAQALGQPIGSLAVGRRADLLVLDGNDPYLASAE
GDALLNRWLFAGGDRQVRDVMVAGRWVVRDGRHAGEERSARAFVQVLGEL
L
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4rzb Chain B Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4rzb Structure of N-Formimino-l-glutamate Iminohydrolase from Pseudomonas aeruginosa.
Resolution1.863 Å
Binding residue
(original residue number in PDB)		H56 H58 H232 D320
Binding residue
(residue number reindexed from 1)		H55 H57 H231 D319
Annotation score1
Enzymatic activity
Enzyme Commision number 3.5.3.13: formimidoylglutamate deiminase.
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0019239 deaminase activity
GO:0046872 metal ion binding
GO:0050416 formimidoylglutamate deiminase activity
Biological Process
GO:0006547 L-histidine metabolic process
GO:0006548 L-histidine catabolic process
GO:0019556 L-histidine catabolic process to glutamate and formamide
GO:0019557 L-histidine catabolic process to glutamate and formate
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4rzb, PDBe:4rzb, PDBj:4rzb
PDBsum4rzb
PubMed25559274
UniProtQ9HU77|HUTF_PSEAE Formimidoylglutamate deiminase (Gene Name=hutF)

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