Structure of PDB 4rxh Chain B Binding Site BS02

Receptor Information

>4rxh Chain B (length=421) Species: 5141 (Neurospora crassa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

DLPKMVEGVFSSEIDKQIQATTKFRKLLSKERNPPIEEVIKTGVVGRFVE
FLRSPHTLVQFEAAWALTNIASGSATQTQVVIEAGAVPIFVELLGSPEPD
VREQAVWALGNIAGDSPQCRDYVLSCGALRPLLTLLGDSRKLSMLRNATW
TLSNFCRGKTPQPDWNTIAPALPVLAKLVYSLDDEVLIDACWAISYLSDG
SNDKIQAVIEAGIPRRLVELLMHASTSVQTPALRSVGNIVTGDDVQTQVI
INCGALPCLLSLLSSNKDGIRKEACWTISNITAGNSAQIQSVIDANIIPP
LIHLLSHADLKTRKEACWAISNATSGGLQKPDQIRYLVAQGCIKPLCDLL
ACPDNKIIQVALDGLENILKVGELDKNAASINRYALFIEECGGMEKIHDC
QTNANEEIYMKAYNIIEKYFS

Ligand information

>4rxh Chain C (length=8) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

PPKKKRKV

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4rxh Structure of Importin-alpha from a Filamentous Fungus in Complex with a Classical Nuclear Localization Signal.
Resolution	1.7553 Å
Binding residue (original residue number in PDB)	L109 S110 K111 E112 P115 W146 N150 A152 S153 G154 Q185 W188 N192 G195 D196 W231 R238 W273
Binding residue (residue number reindexed from 1)	L28 S29 K30 E31 P34 W65 N69 A71 S72 G73 Q104 W107 N111 G114 D115 W150 R157 W192

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0061608	nuclear import signal receptor activity

	Biological Process
GO:0006606	protein import into nucleus

	Cellular Component
GO:0005737	cytoplasm

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:4rxh, PDBe:4rxh, PDBj:4rxh
PDBsum	4rxh
PubMed	26091498
UniProt	Q9C2K9

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