Structure of PDB 4rib Chain B Binding Site BS02

Receptor Information
>4rib Chain B (length=628) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TGHPYYLRSFLVVLKTVLENEDDMLLFDEQEKGIVTKFYQLSATGQKLYV
RLFQRKLSWIKMTKLEYEEIALDLTPVIEELTNAGFLQTESELQELSEVL
ELLSAPELKSLAKTFHLANPNGQKQQLVDAFLKLAKQRSVIGAVILKRAK
ALAGQSVRICKGPRAVFSRILLLFSLTDSMEDEDAACGGQGQLSTVLLVN
LGRMEFPSYTINRKTHIFQDRDDLIRYAAATHMLSDISSAMANGNWEEAK
ELAQCAKRDWNRLKNHPSLRCHEDLPLFLRCFTVGWIYTRILSRFVEILQ
RLHMYEEAVRELESLLSQRIYCPDSRGRWWDRLALNLHQHLKRLEPTIKC
ITEGLADPEVRTGHRLSLYQRAVRLRESPSCKKFKHLFQQLPEMAVQDVK
HVTITGRLCPQRKSVFVMEAGEAADPTTVLCSVEELALAHYRRSGFDQGI
HGEGSTFSTLYGLLLWDIIFMDGIPDVFRNACQAFPLDLCTDSFFTSRRP
ALEARLQLIHDAPEESLRAWVAATWHEQEGRVASLVSWDRFTSLQQAQDL
VSCLGGPVLSGVCRHLAADFRHCRGGLPDLVVWNSQSRHFKLVEVKGPND
RLSHKQMIWLAELQKLGAEVEVCHVVAV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4rib DNA repair. Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1.
Resolution3.25 Å
Binding residue
(original residue number in PDB)		K433 S473 A474 K493
Binding residue
(residue number reindexed from 1)		K64 S104 A105 K124
Binding affinityPDBbind-CN: Kd=10.3nM
Enzymatic activity
Enzyme Commision number 3.1.21.-
3.1.4.1: phosphodiesterase I.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004518 nuclease activity
GO:0016788 hydrolase activity, acting on ester bonds
Biological Process
GO:0036297 interstrand cross-link repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4rib, PDBe:4rib, PDBj:4rib
PDBsum4rib
PubMed25430771
UniProtQ9Y2M0|FAN1_HUMAN Fanconi-associated nuclease 1 (Gene Name=FAN1)

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