Structure of PDB 4rea Chain B Binding Site BS02

Receptor Information
>4rea Chain B (length=588) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EFPYYLRSFLVVLKTVLENEDDMLLFDEQEKGIVTKFYQLSATGQKLYVR
LFQRKLSWIKMTKLEYEEIALDLTPVIEELTNAGFLQTESELQELSEVLE
LLSAPELKSLAKTFHLVNPNGQKQQLVDAFLKLAKQGIGAVILKRAKALA
GQSVRICKGPRAVFSRILLLFSLTDSMEDELLVNLGRMEFPSYTINRKTH
IFQDRDDLIRYAAATHMLSDISSAMANGNWEEAKELAQCAKRDWNRLKNH
PSLRCHEDLPLFLRCFTVGWIYTRILSRFVEILQRLHMYEEAVRELESLL
SQRIYCPDSRGRWWDRLALNLHQHLKRLEPTIKCITEGLADPEVRTGHRL
SLYQRAVRLRESPSCKKFKHLFQQLPEMAVQDVKHVTITLCSVEELALAH
YRRSGFDQGIHGEGSTFSTLYGLLLWDIIFMDGIPDVFRNACQAFPLDLC
TDSFFTSRRPALEARLQLIHDAPEESLRAWVAATWHEQEGRVASLVSWDR
FTSLQQAQDLVSCLGGPVLSGVCRHLAADFRHCRGGLPALVVWNSQSRHF
KLVEVKGPNDRLSHKQMIWLAELQKLGAEVEVCHVVAV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4rea Structural insights into 5' flap DNA unwinding and incision by the human FAN1 dimer.
Resolution3.81 Å
Binding residue
(original residue number in PDB)		S473 A474 Q492 K493
Binding residue
(residue number reindexed from 1)		S103 A104 Q122 K123
Enzymatic activity
Enzyme Commision number 3.1.21.-
3.1.4.1: phosphodiesterase I.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004518 nuclease activity
GO:0016788 hydrolase activity, acting on ester bonds
Biological Process
GO:0036297 interstrand cross-link repair

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4rea, PDBe:4rea, PDBj:4rea
PDBsum4rea
PubMed25500724
UniProtQ9Y2M0|FAN1_HUMAN Fanconi-associated nuclease 1 (Gene Name=FAN1)

[Back to BioLiP]