Structure of PDB 4rb1 Chain B Binding Site BS02

Receptor Information

>4rb1 Chain B (length=132) Species: 1430440 (Magnetospirillum gryphiswaldense MSR-1 v2)

HMVSRIEQRLIDKGLKVTDQRRVIAQVLSDSADHPDVEEVYRRATAKDPI
SIATVYRTVRLFEEESILERHDFGDGRARYEEAPSEHHDHLIDVNARVIE
FTSPEIEALQREIARKHGFRLVGHRLELYGVP

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 4rb1 Chain B Residue 200

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4rb1 Mechanistic insights into metal ion activation and operator recognition by the ferric uptake regulator.
• Resolution: 2.75 Å
• Binding residue (original residue number in PDB): H87 D89 E108 H125
• Binding residue (residue number reindexed from 1): H87 D89 E107 H124
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0000976 transcription cis-regulatory region binding
• GO:0003677 DNA binding
• GO:0003700 DNA-binding transcription factor activity
• GO:0008270 zinc ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006355 regulation of DNA-templated transcription
• GO:0045892 negative regulation of DNA-templated transcription
• GO:1900705 negative regulation of siderophore biosynthetic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:4rb1, PDBe:4rb1, PDBj:4rb1
• PDBsum: 4rb1
• PubMed: 26134419
• UniProt: V6F4Q0