Structure of PDB 4qik Chain B Binding Site BS02
Receptor Information
>4qik Chain B (length=297) Species:
9606
(Homo sapiens) [
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SGVEDTKHYEEAKKCVEELALYLKPLVLSRPMQRKLVTLVHCQLVEEEGR
IRAMRAARSLGERTVTELILQHQNPQQLSSNLWAAVRARGCQFLGPAMQE
EALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKTSIGHVVQLLYR
ASCFKVTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAPD
QWSSLLYGDQSHKSHMQSIIDKLQTPASFAQSVQELTIALQRTGDPANLN
RLRPHLELLANIDPSPDAPPPTWEQLENGLVAVRTVVHGLVDYIQNH
Ligand information
>4qik Chain D (length=18) [
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guuuucugugaaaacgga
..................
Receptor-Ligand Complex Structure
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PDB
4qik
The ROQ domain of Roquin recognizes mRNA constitutive-decay element and double-stranded RNA.
Resolution
1.9 Å
Binding residue
(original residue number in PDB)
S315 Q318 S319 D322
Binding residue
(residue number reindexed from 1)
S214 Q217 S218 D221
Enzymatic activity
Enzyme Commision number
2.3.2.27
: RING-type E3 ubiquitin transferase.
External links
PDB
RCSB:4qik
,
PDBe:4qik
,
PDBj:4qik
PDBsum
4qik
PubMed
25026078
UniProt
Q5TC82
|RC3H1_HUMAN Roquin-1 (Gene Name=RC3H1)
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