Structure of PDB 4pw6 Chain B Binding Site BS02

Receptor Information
>4pw6 Chain B (length=188) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVPSNHYGPIPGIPVGSTWRFRVQVSEAGVHRPHVGGIHGRSNDGAYSLV
LAGGFADEVDRGDEFTYTGSSADQTLTNMNRALALNCDAPLDDKIGAESR
NWRAGKPVRVIRSFKGRKISKYAPEEGNRYDGIYKVVKYWPEISSSHGFL
VWRYLLRRDDVEPAPWTSEGIERSRRLCLRLQYPAGYP
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4pw6 Structural Basis for Hydroxymethylcytosine Recognition by the SRA Domain of UHRF2.
Resolution3.789 Å
Binding residue
(original residue number in PDB)
F461 R462 V475 G476 G477 A492 G494 E498 Y507 S510 K569
Binding residue
(residue number reindexed from 1)
F21 R22 V35 G36 G37 A52 G54 E58 Y67 S70 K115
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
External links
PDB RCSB:4pw6, PDBe:4pw6, PDBj:4pw6
PDBsum4pw6
PubMed24813944
UniProtQ96PU4|UHRF2_HUMAN E3 ubiquitin-protein ligase UHRF2 (Gene Name=UHRF2)

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