Structure of PDB 4p0r Chain B Binding Site BS02

Receptor Information
>4p0r Chain B (length=284) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NAALVTRMKAQRPEECLKHIIVVLDPVLLQMEGGGQLLGALQTMECRCVI
EAQAVPCSVTWRRRAGPSEDREDWVEEPTVLVLLRAEAFVSMIDNGKTLQ
GFVTDITAKTAGKALSLVIVDQEKCFVSRVDAEEALVDLQLHTEAQAQIV
QSWKELADFTCAFTKAVAEAPFKKLRDETTFSFCLESDWAGGVKVDLAGR
GLALVWRRQIQQLNRVSLEMASAVVNAYPSPQLLVQAYQQCFSDKERQNL
LADIQVRRTSRRIGPELSRRIYLQMTTLQPHLSL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4p0r Crystal structures of the structure-selective nuclease Mus81-Eme1 bound to flap DNA substrates.
Resolution6.501 Å
Binding residue
(original residue number in PDB)		K241 G467 S542 G546 P547 E548
Binding residue
(residue number reindexed from 1)		K9 G191 S260 G264 P265 E266
Enzymatic activity
Enzyme Commision number 3.1.22.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004518 nuclease activity
Biological Process
GO:0006281 DNA repair
Cellular Component
GO:0005634 nucleus
GO:0048476 Holliday junction resolvase complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4p0r, PDBe:4p0r, PDBj:4p0r
PDBsum4p0r
PubMed24733841
UniProtQ96AY2|EME1_HUMAN Crossover junction endonuclease EME1 (Gene Name=EME1)

[Back to BioLiP]