Structure of PDB 4ncn Chain B Binding Site BS02

Receptor Information
>4ncn Chain B (length=345) Species: 759272 (Thermochaetoides thermophila DSM 1495) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HMNKDNLRSPICCILGHVDTGKTKLLDKIRQTNVQEGEAGGITQQIGATY
FPVEAIKQKTAVVNKDGKFEFKVPGLLIIDTPGHESFSNLRSRGSSLCNI
AILVVDIMHGLEPQTIESLRLLRERKTPFVVALNKIDRLYGWKKIENNGF
RESFALQNKAVQNEFRNRLDQVKLQFAEQGFNSELFYENKNFARYVSLVP
TSAHTGEGIPDMLKLIVQLCQERMASSLMYLSELQATVLEVKAIEGFGVT
IDVILSNGILREGDRIVLCGLEGPIKTNIRALLTPAPMRELRIKGQYIHH
KEVKAAQGVKISAPGLEGAIAGSRLLVVGPDDDEEELEEEVESDL
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain4ncn Chain B Residue 1002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4ncn eIF5B employs a novel domain release mechanism to catalyze ribosomal subunit joining.
Resolution1.87 Å
Binding residue
(original residue number in PDB)		T537 T557
Binding residue
(residue number reindexed from 1)		T23 T43
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.5.3: protein-synthesizing GTPase.
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:4ncn, PDBe:4ncn, PDBj:4ncn
PDBsum4ncn
PubMed24686316
UniProtG0S8G9|IF2P_CHATD Eukaryotic translation initiation factor 5B (Gene Name=CTHT_0029840)

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