Structure of PDB 4ncb Chain B Binding Site BS02

Receptor Information
>4ncb Chain B (length=672) Species: 274 (Thermus thermophilus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVARRAG
GVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPKDPG
ERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGAVLD
LWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRTWEL
LRLGEEDPKELPLPGGLSLLDYHASKGRLQGREGGRVAWVADPIPHLTGL
LVPVLTLEDLHESLALSLPWEERRRRTREIASWIGRRLGLGTPEAVRAQA
YRLSIPKLMGRRAVSKPADALRVGFYRAQETALALLRLDGAQGWPEFLRR
ALLRAFGASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAVLVLTPPM
AWEDRNRLKALLLREGLPSQILNVPLREEERHRWENALLGLLAKAGLQVV
ALSGAYPAELAVGFDAGGRESFRFGGAACAVGGDGGHLLWTLPEAQAGER
IPQEVVWDLLEETLWAFRRKAGRLPSRVLLLRDGRVPQDEFALALEALAR
EGIAYDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVHRDFRGT
PRPLKLVHEAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPLHLADRLV
KEVGRLGIRHLKEVDREKLFFV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4ncb Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage.
Resolution2.189 Å
Binding residue
(original residue number in PDB)		E268 S276 A278 S328 K329 W415 H445 D478 G480 G481 K575 D590 V606 R608 F610 F647 A648 F649 R668
Binding residue
(residue number reindexed from 1)		E258 S263 A265 S315 K316 W402 H432 D465 G467 G468 K562 D577 V593 R595 F597 F634 A635 F636 R655
Enzymatic activity
Enzyme Commision number 3.1.24.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004520 DNA endonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0044355 clearance of foreign intracellular DNA

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Molecular Function
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Biological Process
External links
PDB RCSB:4ncb, PDBe:4ncb, PDBj:4ncb
PDBsum4ncb
PubMed24374628
UniProtQ746M7|AGO_THET2 Protein argonaute (Gene Name=ago)

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