Structure of PDB 4n76 Chain B Binding Site BS02

Receptor Information
>4n76 Chain B (length=667) Species: 274 (Thermus thermophilus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGRVYPLLAQVARRAG
GVTVRMGDGLASWSPPEVLVLEGTLARQTYAYRLYPKGRRPLDPKDPGER
SVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGAVLDLW
VSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRTWELLR
LEDPKELPLPGGLSLLDYHASKGRLQGREGGRVAWVARKPIPHLTGLLVP
VLTLEDLSLALSLPWEERRRRTREIASWIGRRLGLGTPEAVRAQAYRLSI
PKLMGRRAVSKPADALRVGFYRAQETALALLRLDGAQGWPEFLRRALLRA
FGASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAVLVLTPPMAWEDR
NRLKALLLREGLPSQILNVPLREEERHRWENALLGLLAKAGLQVVALSGA
YPAELAVGFDAGGRESFRFGGAACAVGGDGGHLLWTLPEAQAGERIPQEV
VWDLLEETLWAFRRKAGRLPSRVLLLRDGRVPQDEFALALEALAREGIAY
DLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVHRDFRGTPRPLK
LVHEAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPLHLADRLVKEVGR
LGIRHLKEVDREKLFFV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4n76 Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage.
Resolution2.89 Å
Binding residue
(original residue number in PDB)		E268 S328 K329 H445 G481 K575 D590 V606 R608 F647 F649 K664
Binding residue
(residue number reindexed from 1)		E255 S310 K311 H427 G463 K557 D572 V588 R590 F629 F631 K646
Enzymatic activity
Enzyme Commision number 3.1.24.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004520 DNA endonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0044355 clearance of foreign intracellular DNA

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Molecular Function
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Biological Process
External links
PDB RCSB:4n76, PDBe:4n76, PDBj:4n76
PDBsum4n76
PubMed24374628
UniProtQ746M7|AGO_THET2 Protein argonaute (Gene Name=ago)

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