Structure of PDB 4mtt Chain B Binding Site BS02

Receptor Information

>4mtt Chain B (length=127) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MRILHSMLRVADLEAALEFYTRALDMRLLRRRDYPEGRFTLAFVGYQDER
AAAALELTHNWDRDGYTQGDGYGHLAIEVEDAAVTCARARALGYRVTREA
GLMQHGRSVIAFLEDPDGYKVELIQKG

Ligand information

InChI=1S/Zn/q+2

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Zn

Name

ZINC ION

PDB chain

4mtt Chain B Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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PDB	4mtt The crystal structure of a homodimeric Pseudomonas glyoxalase I enzyme reveals asymmetric metallation commensurate with half-of-sites activity.
Resolution	2.17 Å
Binding residue (original residue number in PDB)	H105 E122
Binding residue (residue number reindexed from 1)	H105 E122
Annotation score	1

Enzymatic activity

Catalytic site (original residue number in PDB)	H5 E56 H74 E122
Catalytic site (residue number reindexed from 1)	H5 E56 H74 E122
Enzyme Commision number	4.4.1.5: lactoylglutathione lyase.

Gene Ontology

	Molecular Function
GO:0004462	lactoylglutathione lyase activity
GO:0016829	lyase activity
GO:0046872	metal ion binding

	Biological Process
GO:0019243	methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

	Cellular Component
GO:0005737	cytoplasm

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Cellular Component

External links

PDB	RCSB:4mtt, PDBe:4mtt, PDBj:4mtt
PDBsum	4mtt
PubMed	25411134
UniProt	Q9I5L8

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