Structure of PDB 4lt6 Chain B Binding Site BS02

Receptor Information
>4lt6 Chain B (length=462) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HYGITSPISLASPKEIDHIYTQKLIDAMKPFGVFEDEEELNHRLVVLGKL
NNLVKEWISDVSESKNLPPSVVATVGGKIFTFGSYRLGVHTKGADIDALC
VAPRHVERSDFFQSFFEKLKHQDGIRNLRAVEDAFVPVIKFEFDGIEIDL
VFARLAIQTISDNLDLRDDSRLRSLDIRCIRSLNGCRVTDEILHLVPNKE
TFRLTLRAVKLWAKRRGIYSNMLGFLGGVSWAMLVARTCQLYPNAAASTL
VHKFFLVFSKWEWPNPVLLKQPEESNLNLPVWDPRVNPSDRYHLMPIITP
AYPQQNSTYNVSTSTRTVMVEEFKQGLAVTDEILQGKSDWSKLLEPPNFF
QKYRHYIVLTASASTEENHLEWVGLVESKIRVLVGNLERNEFITLAHVNP
QSFPGNYVSMWFLGIIFRDLTYDIQSFTDTVYRQANNINMLKEGMKIEAT
HVKKKQLHHYLP
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain4lt6 Chain B Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4lt6 Crystal structure of human poly(a) polymerase gamma reveals a conserved catalytic core for canonical poly(a) polymerases.
Resolution2.79 Å
Binding residue
(original residue number in PDB)		D112 D114
Binding residue
(residue number reindexed from 1)		D95 D97
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) S101 D112 D114 D166 K227 Y236
Catalytic site (residue number reindexed from 1) S84 D95 D97 D149 K210 Y219
Enzyme Commision number 2.7.7.19: polynucleotide adenylyltransferase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0016779 nucleotidyltransferase activity
GO:1990817 poly(A) RNA polymerase activity
Biological Process
GO:0031123 RNA 3'-end processing
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4lt6, PDBe:4lt6, PDBj:4lt6
PDBsum4lt6
PubMed24076191
UniProtQ9BWT3|PAPOG_HUMAN Poly(A) polymerase gamma (Gene Name=PAPOLG)

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