Structure of PDB 4kif Chain B Binding Site BS02

Receptor Information

>4kif Chain B (length=339) Species: 1912 (Streptomyces hygroscopicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SHMSTEVSEAQARRAVADIFNSTLASSAIGAAWELGALDELRENGKLDVS
DFAVRHDLHEPAVVGMFTALASVGIVRREGATVVVGPYFDEANHHRSLFH
WLNQGSGELFRRMPQVLPNENRTGKFYQRDAGAISYACREISERYFDPAF
WAAVDGLGYTPTTVADLGSGSGERLIQIARRFPGVRGLGVDIADGAIAMA
EKEVAAKGFGDQISFVRGDARTIDQVSARGEFAEVDLLTCFMMGHDFWPR
ENCVQTLRKLRAAFPNVRRFLLGDATRTVGIPDRELPVFTLGFEFGHDMM
GVYLPTLDEWDGVFEEGGWRCVKKHAIDSLSVSVVFELE

Ligand information

Ligand ID

InChI

InChI=1S/Fe/q+3

InChIKey

VTLYFUHAOXGGBS-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 CACTVS 3.341 OpenEye OEToolkits 1.5.0	[Fe+3]

Formula

Name

FE (III) ION

PDB chain

4kif Chain B Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	4kif Structure and mechanism of a nonhaem-iron SAM-dependent C-methyltransferase and its engineering to a hydratase and an O-methyltransferase
Resolution	2.5 Å
Binding residue (original residue number in PDB)	H243 D244 H295
Binding residue (residue number reindexed from 1)	H245 D246 H297
Annotation score	1

Enzymatic activity

Enzyme Commision number

2.1.1.281: phenylpyruvate C(3)-methyltransferase.

Gene Ontology

	Molecular Function
GO:0008168	methyltransferase activity

	Biological Process
GO:0009058	biosynthetic process
GO:0017000	antibiotic biosynthetic process
GO:0032259	methylation

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:4kif, PDBe:4kif, PDBj:4kif
PDBsum	4kif
PubMed	24914966
UniProt	Q643C8\|MPPJ_STRHY Phenylpyruvate C(3)-methyltransferase (Gene Name=mppJ)

[Back to BioLiP]