Structure of PDB 4jrp Chain B Binding Site BS02

Receptor Information
>4jrp Chain B (length=465) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QQSTFLFHDYETFGTHPALDRPAQFAAIRTDSEFNVIGEPEVFYCKPADD
YLPQPGAVLITGITPQEARAKGENEAAFAARIHSLFTVPKTCILGYNNVR
FDDEVTRNIFYRNFYDPYAWSWQHDNSRWDLLDVMRACYALRPEGINWPE
NDDGLPSFRLEHLTKANGIEHDAMADVYATIAMAKLVKTRQPRLFDYLFT
HRNKHKLMALIDVPQMKPLVHVSGMFGAWRGNTSWVAPLAWHPENRNAVI
MVDLAGDISPLLELDSDTLRERLYTAKTDLGDNAAVPVKLVHINKCPVLA
QANTLRPEDADRLGINRQHCLDNLKILRENPQVREKVVAIFAEAEPFTPS
DNVDAQLYNGFFSDADRAAMKIVLETEPRNLPALDITFVDKRIEKLLFNY
RARNFPGTLDYAEQQRWLEHRRQVFTPEFLQGYADELQMLVQQYADDKEK
VALLKALWQYAEEIV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4jrp Crystal structures of Escherichia coli exonuclease I in complex with single-stranded DNA provide insights into the mechanism of processive digestion.
Resolution1.95 Å
Binding residue
(original residue number in PDB)		E17 T18 T21 A63 N103 F107 R113 D122 Y124 W128 N255 N257 L283 Y284 A286 N304 F351 E355 P356 F357 Y368 F371 R377
Binding residue
(residue number reindexed from 1)		E11 T12 T15 A57 N97 F101 R107 D116 Y118 W122 N245 N247 L273 Y274 A276 N294 F341 E345 P346 F347 Y358 F361 R367
Enzymatic activity
Enzyme Commision number 3.1.11.1: exodeoxyribonuclease I.
Gene Ontology
Molecular Function
GO:0000175 3'-5'-RNA exonuclease activity
GO:0000287 magnesium ion binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003697 single-stranded DNA binding
GO:0004527 exonuclease activity
GO:0004529 DNA exonuclease activity
GO:0005515 protein binding
GO:0008310 single-stranded DNA 3'-5' DNA exonuclease activity
GO:0046872 metal ion binding
GO:0051575 5'-deoxyribose-5-phosphate lyase activity
Biological Process
GO:0006259 DNA metabolic process
GO:0006274 DNA replication termination
GO:0006281 DNA repair
GO:0006308 DNA catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4jrp, PDBe:4jrp, PDBj:4jrp
PDBsum4jrp
PubMed23609540
UniProtP04995|EX1_ECOLI Exodeoxyribonuclease I (Gene Name=sbcB)

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