Structure of PDB 4j4m Chain B Binding Site BS02

Receptor Information
>4j4m Chain B (length=200) Species: 103944 (Protobothrops mucrosquamatus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RFPQRYVMLAIVADHGMVTKYSGNSSAITTRVHQMVSHVTEMYSPLNIAT
TLSLLRIWSSKDLITVQSDSSVTLGSFGDWRKVVLLSQQAHDCAFLNTAT
ALDDSTIGLAYSNGMCDPKFSVGLVQDHSSNVFMVAVTMTHELGHNLGMA
HDEAGGCACSSCIMSPAASSGPSKLFSDCSKDDYQTFLTNTNPQCILNAP
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4j4m Chain B Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4j4m Crystal structure of a Trimeresurus mucrosquamatus venom metalloproteinase providing new insights into the inhibition by endogenous tripeptide inhibitors.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		D72 D106
Binding residue
(residue number reindexed from 1)		D69 D103
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.24.-
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4j4m, PDBe:4j4m, PDBj:4j4m
PDBsum4j4m
PubMed23732127
UniProtU3KRG1|VM1T1_PROMU Snake venom metalloproteinase TM-1

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