Structure of PDB 4irp Chain B Binding Site BS02

Receptor Information

>4irp Chain B (length=227) Species: 9606 (Homo sapiens)

GSDIPEHWEEDASWGPHRLAVLVPFRERFEELLVFVPHMRRFLSRKKIRH
HIYVLNQVDHFRFNRAALINVGFLESSNSTDYIAMHDVDLLPLNEELDYG
FPEAGPFHVASPELHPLYHYKTYVGGILLLSKQHYRLCNGMSNRFWGWGR
EDDEFYRRIKGAGLQLFRPSGITTGYKTFRHLREGGLNTVKYHVASRTAL
SVGGAPCTVLNIMLDCDKTATPWCTFS

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 4irp Chain B Residue 402

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4irp Crystal Structures of beta-1,4-Galactosyltransferase 7 Enzyme Reveal Conformational Changes and Substrate Binding.
• Resolution: 2.1 Å
• Binding residue (original residue number in PDB): D165 H257
• Binding residue (residue number reindexed from 1): D89 H181
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): D163 D165 W224 E227 D228 T254 H257
• Catalytic site (residue number reindexed from 1): D87 D89 W148 E151 D152 T178 H181
• Enzyme Commision number: 2.4.1.-
  2.4.1.133: xylosylprotein 4-beta-galactosyltransferase.

Gene Ontology

Molecular Function

• GO:0016757 glycosyltransferase activity

Biological Process

• GO:0005975 carbohydrate metabolic process

External links

• PDB: RCSB:4irp, PDBe:4irp, PDBj:4irp
• PDBsum: 4irp
• PubMed: 24052259
• UniProt: Q9UBV7|B4GT7_HUMAN Beta-1,4-galactosyltransferase 7 (Gene Name=B4GALT7)