Structure of PDB 4iqr Chain B Binding Site BS02

Receptor Information
>4iqr Chain B (length=308) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKD
KRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQ
AEVLSDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVAL
LRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRIL
DELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSL
EDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNL
LQEMLLGG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4iqr Multidomain integration in the structure of the HNF-4 alpha nuclear receptor complex.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		D69 G70 R77 R100 N101 R104 R107 R125 I128
Binding residue
(residue number reindexed from 1)		D21 G22 R29 R52 N53 R56 R59 R77 I80
Binding affinityPDBbind-CN: Kd=80nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0003707 nuclear steroid receptor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4iqr, PDBe:4iqr, PDBj:4iqr
PDBsum4iqr
PubMed23485969
UniProtP41235|HNF4A_HUMAN Hepatocyte nuclear factor 4-alpha (Gene Name=HNF4A)

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