Structure of PDB 4iqj Chain B Binding Site BS02

Receptor Information
>4iqj Chain B (length=1167) Species: 271 (Thermus aquaticus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LKFAHLHQHTQFSLLDGAAKLQDLLKWVKETTPEDPALAMTDHGNLFGAV
EFYKKATAMGVKPIIGYEAYVAAESRFDRGYFHLTLLAKDFTGYQNLVRL
ASRAYLEGFYEKPRIDREILREHAQGLIALSGCLGAEIPQFILQDRLDLA
EARLNEDLSIFGDRFFIEIQNHGLPEQKKVNQVLKEFARKYGLGMVATND
GHYVRKEDARAHEVLLAIQSKTTLDDPERWRFPCDEFYVKTPEEMRAMLP
EAEWGDEPFDNTVEIARMCDVDLPIGDKMVYRIPRFPLPEGRTEAQYLRE
LTFLGLLRRYPDRITEAFYREVLRLLDERALAEALARVEEKAWEELREWT
AEAILHRALYELSVIERMGFPGYFLIVQDYINWARGHGVSVGPGRGSAAG
SLVAYAVGITNIDPLRFGLLFERFLNPERVSMPDIDTDFSDRERDRVIQY
VRERYGEDKVAQIGTASKAALKDVARVIPHKKAEELAKLIPPKPLQEAEL
RAEMEKDERIRQVIEVAMRLEGLNRHASVHAAGVVIAAEPLTDLVPLMRD
QEGRPVTQYDMGAVEALGLLKMDFLGLRTLTFLDEARRIVKESKGVELDY
DRLPLDDPKTFELLSRGETKGVFQLESGGMTATVRGLKPRRLEDIIALVS
LYRPGPMEHIPTYIRRHHGQEPVSYAEFPHAEKYLRPILDETYGIPVYQE
QIMQIASQVAGYSLGEADLLRRAMGKKRVEEMQKHRERFVRGAKERGVPE
EEANRLFDMLEAFANYGFNKSHAAAYSLLSYQTAYVKAHYPVEFMAALLS
VERHDSDKVAEYIRDARALGIPVLPPDVNRSGFDFKVVGEEILFGLSAVK
NVGEMAARAILEERERGGPFKSLGDFLKRLPEQVVNKRALESLVKAGALD
AFGDRARLLASLEPLLRWAAETRERGRSGLVGLFAEVEEPPLVEASPLDE
ITMLRYEKEALGIYVSGHPVLRYPGLREVASCTIEELSEFVRELPGKPKV
LLSGMVEEVVRKPTGMMARFTLSDETGALEVVVFGRAYEGVSPKLKEDIP
LLVLAEVERVLAQAVWTLEEVLEAPKALEVEVDHALLDEKGVARLKSLLD
EHPGSLPVYLRVLGPFGEALFALREVRVGEEALGLLEAEGYRAYLVPDRE
VFLQGNGGGPKEEVVPF
Ligand information
Receptor-Ligand Complex Structure
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PDB4iqj Structure of PolIIIalpha-Tauc-DNA complex suggests an atomic model of the replisome
Resolution3.2 Å
Binding residue
(original residue number in PDB)		R424 P526 P532 E597 H817 Q928
Binding residue
(residue number reindexed from 1)		R395 P491 P492 E552 H772 Q883
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003887 DNA-directed DNA polymerase activity
GO:0008408 3'-5' exonuclease activity
Biological Process
GO:0006260 DNA replication
GO:0071897 DNA biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4iqj, PDBe:4iqj, PDBj:4iqj
PDBsum4iqj
PubMed23478062
UniProtQ9XDH5|DPO3A_THEAQ DNA polymerase III subunit alpha (Gene Name=dnaE)

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